Dr. Nathan S. Bryan

In the intricate world of biotechnology and molecular medicine, few names carry the weight and innovation of Dr. Nathan S. Bryan. As the Founder, Chairman, and CEO of Bryan Therapeutics Inc., he is not merely leading a biotech company—he is leading a revolution. At the forefront of nitric oxide science, Dr. Bryan has spent over two decades redefining how this vital signaling molecule can be leveraged to prevent, manage, and even reverse some of the most complex chronic diseases of our time. His journey bridges academia and industry, scientific theory and commercial success, all centered around one powerful mission: to unlock the therapeutic potential of nitric oxide and bring its benefits to patients on a global scale.

From Biochemical Curiosity to Lifesaving Discovery
Dr. Nathan Bryan's fascination with nitric oxide began early in his academic career, rooted in a strong educational foundation that included a Bachelor of Science in Biochemistry from the University of Texas at Austin, followed by a Ph.D. from LSU Health Sciences Center. It was during these formative years that he realized the untapped potential of nitric oxide, a molecule once regarded as merely a byproduct of metabolic processes. Dr. Bryan pursued postdoctoral training as a Kirschstein Fellow at Boston University, deepening his knowledge at the Whitaker Cardiovascular Institute. His scientific pedigree was further enriched when he joined the University of Texas Health Science Center at Houston, where he was recruited by Nobel Laureate Dr. Ferid Murad, a co-recipient of the Nobel Prize for the discovery of nitric oxide as a signaling molecule in the cardiovascular system. Working alongside legends in the field, Dr. Bryan began to formulate his own vision—a comprehensive approach to nitric oxide science that not only expanded its theoretical framework but also translated that knowledge into real-world applications.

A Lifetime of Research Transformed into Real-World Breakthroughs
Across more than 25 years of research, Dr. Bryan has authored or co-authored over 100 peer-reviewed publications and holds more than 100 U.S. and international patents in the field of nitric oxide therapeutics. His groundbreaking work helped reclassify dietary nitrate and nitrite from inert molecules to crucial precursors for nitric oxide production in the human body. He was among the first to demonstrate that nitric oxide could be replenished externally when the body’s natural production declines—a key insight in treating conditions such as cardiovascular disease, Alzheimer’s, diabetes, erectile dysfunction, and even chronic wounds. His research has consistently proven that nitric oxide is not only foundational to vascular health but also essential in cellular communication, immune modulation, and neuroprotection. What separates Dr. Bryan from many of his peers, however, is not just the scale of his contributions but his ability to bring them to life through commercial and clinical channels.

Building Bryan Therapeutics: Merging Science, Strategy, and Scale
With a strong academic foundation and a treasure trove of intellectual property, Dr. Bryan founded Bryan Therapeutics Inc. with a clear and compelling goal: to develop and commercialize nitric oxide–based therapies that can improve and save lives. As CEO, he has built the company into a dynamic, clinical-stage biotechnology platform focused on advancing proprietary drugs for some of today’s most debilitating conditions. From ischemic heart disease and neurodegenerative disorders to diabetic foot ulcers and pressure sores, the therapeutic portfolio under his leadership is as diverse as it is promising. The 2023 acquisition of Nitric Oxide Innovations (NOi), a company he previously founded, further accelerated clinical development and expanded Bryan Therapeutics’ pipeline into respiratory, metabolic, and infectious diseases. For Dr. Bryan, this acquisition was not just a strategic consolidation—it was a reaffirmation of his belief that nitric oxide therapeutics can and should be central to modern medicine.

Proven Clinical Impact with Global Potential
Dr. Bryan’s technologies are not confined to the lab; they are already showing promise in clinical settings. His nitric oxide–based therapies have been evaluated in clinical trials for treating COVID-19, demonstrating antiviral, anti-inflammatory, and oxygenation benefits. More notably, his work is paving the way for FDA-regulated therapeutics that may offer new hope for millions of patients suffering from chronic cardiovascular and neurovascular conditions. These treatments don’t just alleviate symptoms—they aim to restore nitric oxide function at the cellular level, addressing the root causes of systemic dysfunction. As nitric oxide deficiency is now understood to be a central factor in many age-related diseases, Dr. Bryan’s work stands at the precipice of reshaping how we approach everything from aging to neurodegeneration. With multiple candidates progressing through the regulatory pipeline, Bryan Therapeutics is poised to emerge as a leader in next-generation medicine.

Entrepreneurial Expansion into Consumer Health and Wellness
In parallel with his pharmaceutical pursuits, Dr. Bryan has also made significant strides in the consumer health space. He co-founded several successful companies that introduced nitric oxide–enhancing supplements to the mass market, including SuperBeets, Neo40, and NO2U. These over-the-counter products have achieved widespread consumer adoption, with global revenues estimated in the hundreds of millions. Unlike many supplement brands that rely on marketing hype, Dr. Bryan’s formulations are backed by scientific validation and human clinical data. By bridging the gap between prescription therapeutics and consumer wellness, he has effectively democratized access to nitric oxide science. This dual-pronged approach—targeting both medical and lifestyle audiences—reflects his belief that health optimization should begin long before disease manifests. His venture Pneuma Nitric Oxide further expanded this vision by offering nitric oxide–based skincare products that improve circulation, collagen synthesis, and cellular repair.

Leadership Philosophy Anchored in Purpose and Science
Dr. Bryan is not only a gifted scientist and entrepreneur—he is a purpose-driven leader with a profound sense of responsibility. He sees his role as a guardian of public health innovation, someone who must not only discover new knowledge but also ensure that it reaches those who need it most. His leadership style is defined by scientific rigor, business agility, and ethical commitment. He actively mentors the next generation of nitric oxide researchers, invests in collaborative partnerships with universities and government agencies, and advocates for evidence-based wellness at major global forums. His appointment to the Forbes Business Council and frequent participation in industry think tanks reflect his growing influence beyond the lab and into the boardroom, policy arenas, and public discourse. His upcoming book, “The Secret of Nitric Oxide: Bringing Nitric Oxide to Life,” slated for release in 2025, aims to bridge the gap between molecular science and public understanding, inviting readers into the miraculous world of nitric oxide as the key to vitality and longevity.

A Vision for the Future of Medicine
Dr. Nathan S. Bryan envisions a future where nitric oxide therapeutics become as foundational to medicine as antibiotics or insulin. He believes that in the next decade, we will see nitric oxide therapy integrated into mainstream treatment protocols for cardiovascular disease, neurodegenerative conditions, diabetes, and immune dysfunction. His research is already influencing how hospitals approach wound care and circulatory disorders, with nitric oxide-based dressings and topical agents entering pilot programs. Moreover, as precision medicine continues to evolve, Dr. Bryan is exploring how nitric oxide biomarkers can be used to personalize treatments and track disease progression in real time. From gene expression to microbiome interactions, he is extending nitric oxide research into new frontiers with profound implications for the way we understand health and disease.

A Legacy of Scientific Excellence and Human Impact
Dr. Nathan S. Bryan’s legacy is still unfolding, but it is already one marked by extraordinary achievement, scientific innovation, and profound humanitarian impact. He has built a career not just on discovery, but on application—on ensuring that the insights gleaned from decades of research translate into therapies that improve lives. As CEO of Bryan Therapeutics Inc., he continues to lead with vision and clarity, shaping the trajectory of nitric oxide science with unmatched dedication. In a world facing escalating health challenges and chronic disease burdens, his work offers not only answers but hope. For those who believe in the power of science to transform society, Dr. Bryan stands as a shining example of what is possible when intellect, integrity, and innovation converge.